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Exquisite sensitivity of the prostate to androgenic steroids has provided support for the development of systemic therapy for prostate cancer for more than seventy years. Standing strategic approach that focused on inhibiting this unique signaling pathwayled to the use of androgen-deprivation and antiandrogen therapyfor LIMKO inhibitor, kinase that acts downstream of the rock topromote actin assembly, blocked the thickening of the skin and reduces b-catenin levels in K14-rock : ER mice. Likewise, the increase in collagen was found to be reduced. To check whether the rocks (Rho-associated coiled-coil forming protein serine /threonine kinase) activation would affect tumor growth andprogression of skin papillomas are caused by chemical twosteptumorigenesis using dimethyl benzal anthracene (DMBA) and 12-Otetradecanoylphorbol-13-acetate (TPA). Through a mechanism that involves mutations HraĊĦe and subsequent MAPkinase activation, skin papillomas appear and a small percentage progress to inva